A new study found that high doses of LSD, combined with assisted therapy, led to greater reductions in depression compared to low doses. Researchers are further investigating LSD-assisted therapy for depression in a larger trial. The FDA granted "breakthrough therapy" status for LSD as a treatment for generalized anxiety disorder.

New Study Finds Higher LSD Doses More Effective at Reducing Depression

Jun 20, 2025

Source:

Staff

Marijuana Moment

A recent study out of Switzerland is shining a bright light on the therapeutic power of psychedelics, specifically LSD. Researchers found that patients struggling with moderate-to-severe depression saw much more significant relief when taking higher doses (100-200μg) compared to those on a microdose-style regimen. Even better, these positive vibes weren't just a flash in the pan; the improved mental clarity lasted for up to three months after the sessions. While LSD has a longer "trip" time than mushrooms, which makes it a bit more of a commitment for clinics, the FDA is already taking note by granting it breakthrough status for anxiety.

For the cannabis community, this is a massive win because it proves that "alternative" substances are finally being taken seriously by the medical establishment. As LSD moves toward potential Phase 3 trials, it paves the way for a more open-minded approach to plant medicine and psychedelics alike. For everyday tokers, this shift in the clinical world means more options for mental health and a future where our favorite herbs and healers are no longer stuck in the shadows.

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