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A study from Johns Hopkins University published in JAMA Network found that psilocybin was significantly more effective than nicotine patches for smoking cessation. Researchers reported that 40% of participants receiving psilocybin treatment successfully quit smoking after six months, compared to only 10% of those using nicotine patches.

Study Suggests Psilocybin Can Help Smokers Quit

Mar 20, 2026

Graham Abbott

Ganjapreneur



A recent study published by Johns Hopkins University researchers comparing
psilocybin against nicotine patches found that participants who were given
a single dose of the psychedelic were six times more likely to abstain from
smoking than those who were given the patch, according to an NPR report.

The study, a randomized trial of 82 smokers, was published this week in the
JAMA Network. The researchers noted that after a six-month follow-up, about
40% of the participants who were given a psilocybin treatment had quit
smoking, while only about 10% of those who were given the patch had stopped.

The researchers also noted that the abstinence rates among those who were
given the psychedelic “were higher than typical treatments, suggesting
promise for tobacco smoking cessation.”

The study’s lead author and a psychiatry professor at Johns Hopkins,
Matthew Johnson, told NPR he was “surprised by the sheer magnitude of the
effect.”

The participants who received psilocybin were given a high dose, according
to the report. Additionally, there was no placebo with the test, so
everyone who was given psilocybin was aware they were receiving the drug,
which the researchers noted could have skewed the results.

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