A recent study published in Science Advances by researchers at the HUN Biological Research Centre in Hungary found that dimethyltryptamine (DMT), a naturally occurring psychedelic, protects against stroke damage in animal and cell models. DMT, a psychoactive compound found in plants and animals (including the human brain) and a primary ingredient in ayahuasca, mitigated post-stroke effects by stabilizing the blood-brain barrier and reducing neuroinflammation. This dual action offers a novel, complex approach to complement existing stroke treatments, which are currently very limited. A separate, non-peer-reviewed study in 2023 also suggested that DMT treatments with therapy could improve depression symptoms.

Study Shows DMT Helps Brains Heal From Stroke Damage

Oct 8, 2025

Graham Abbott

Ganjapreneur

A recent study found that dimethyltryptamine, the naturally occurring
psychedelic commonly known as DMT, protects against stroke damage in animal
and cell models, Neuroscience News reports.

For the study, published in Science Advances, researchers at the HUN
Biological Research Centre in Hungary tested the effects of DMT in rat
stroke models and cell cultures.

DMT is a psychoactive compound that occurs naturally in a variety of plants
and animals — including the human brain — and it is the primary ingredient
in ayahuasca, a psychedelic used in religious ceremonies by some Indigenous
cultures in South America. It is also being studied in clinical trials as a
potential treatment for stroke damage, according to the report.

The study authors said their “findings prove that DMT mitigates a
poststroke effect by stabilizing the blood-brain barrier and reducing
neuroinflammation.”

Strokes are caused when a blood clot blocks or reduces blood flow to the
brain. Current treatment options involve physically breaking up and
removing the clots using medication or surgery.

“The therapeutic options currently available for stroke are very limited.
The dual action of DMT, protecting the blood-brain barrier while reducing
brain inflammation, offers a novel, complex approach that could complement
existing treatments.” — Judit Vigh, study co-first author, via Neuroscience
News

A non-peer-reviewed study in 2023 found that DMT treatments coupled with
therapy could improve symptoms of depression.

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